Role of integrons in the proliferation of multiple drug resistance in selected bacteria occurring in poultry production.
Br Poult Sci. 2019 Nov 27;:
Authors: Racewicz P, Majewski M, Madeja ZE, Łukomska A, Kubiak M
The increase in microbial resistance, and in particular multiple drug resistance (MDR), is an increasingly threat to public health. The uncontrolled use of antibiotics and antibacterial chemotherapeutics in the poultry industry, especially in concentrations too low to cause inhibition, and the occurrence of residues in feed and in the environment, play a significant role in the development of resistance among zoonotic food-borne microorganisms.Determining the presence and transmission methods of resistance in bacteria is crucial for tracking and preventing antibiotic resistance. Advances in molecular biology (especially in genomics and proteomics), identifying horizontal transfer of genetic elements responsible for drug resistance, is considered the main mechanism for the spread of antibiotic resistance.Of the many well-known genetic elements responsible for horizontal gene transfer, integrons are among the most important factors contributing to multiple drug resistance. The mechanism of bacterial drug resistance acquisition through integrons is one of the essential elements of MDR prevention in animal production.
PMID: 31774316 [PubMed - as supplied by publisher]