Screening and detection of antimicrobials from Dai pharmaceuticals against clinical diseases by methicillin-resistant Staphylococcus aureus

Lett Appl Microbiol. 2021 Oct 12. doi: 10.1111/lam.13583. Online ahead of print.

ABSTRACT

Oroxylum indicum is one of valuable Dai pharmaceutical, the dry seeds and bark of O. indicum were used to treat acute cough, sore throat and so on. Of the seven compounds from O. indicum were determined and obtained using bioassay-guided method. Among them, compound 7 was obtained from the plant for the first time. Eight bacterial strains and one yeast fungi were exposed to the compounds. Minimum inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs) or minimum fungicidal concentrations (MFCs) were determined according to the standard broth microdilution method. Baicalein (2) exhibited relative strong antibacterial activities with MIC of 8 μg.ml-1 and MBC of 16 μg.ml-1 against three MRSA strains of Staphylococcus aureus of SCCmec III type. While flavonoids 3, 5 and 7 showed some degree of activities against methicillin-susceptible Staphylococcus aureus (MSSA, ATCC25923). The findings may offer new evidences that why O. indicum was used widely in Dai peoples' life.

PMID:34637544 | DOI:10.1111/lam.13583