Secondary metabolites isolated from the deep sea-derived fungus Aspergillus sydowii C1-S01-A7.

Secondary metabolites isolated from the deep sea-derived fungus Aspergillus sydowii C1-S01-A7.

Nat Prod Res. 2018 Sep 25;:1-6

Authors: Wang W, Gao M, Luo Z, Liao Y, Zhang B, Ke W, Shao Z, Li F, Chen J

Abstract
Two novel compounds, 2-hydroxy-6-formyl-vertixanthone (1) and 12-O-acetyl-sydowinin A (2), were obtained from the culture of a deep sea-derived fungus Aspergillus sydowii C1-S01-A7, together with twenty-two known compounds (3-24). Their structures were elucidated based on extensive spectroscopic methods. Compounds 4, 8 and 12 showed antibacterial activities against Vibrio rotiferianus and Vibrio vulnificus. Compounds 1, 2, 7, 8, 11 and 12 exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus. Remarkably, compound 8 displayed selectively cytotoxic activity against A549 and strongest cytotoxic activities for both A549 and HepG2 in comparison to the remaining compounds. [Figure: see text].

PMID: 30251547 [PubMed - as supplied by publisher]