Stigmastane-type steroid saponins from the leaves of Vernonia amygdalina Del.

Icon for Elsevier Science Related Articles

Stigmastane-type steroid saponins from the leaves of Vernonia amygdalina Del.

Fitoterapia. 2021 Jan 27;:104838

Authors: Zhao ML, Shan SJ, Tao R, Cui LT, Li QR, Luo J, Li Y

Abstract
Vernoramyosides A-F (1-6), six new Δ7,9(11) stigmastane-type steroid saponins, along with four known analogues (7-10) were isolated from the leaves of Vernonia amygdalina Delile (Compositae). Their structures were determined by the combination of NMR, ECD and HR-ESI-MS data. These compounds all possessed highly oxidized side chain and a γ-lactam or α,β-unsaturated five-membered lactone ring. All isolates were screened for their activities in reversing resistance in MCF/DOX cells.

PMID: 33515649 [PubMed - as supplied by publisher]