Synthesis and bioactivity of antitubercular peptides and peptidomimetics: an update.

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Synthesis and bioactivity of antitubercular peptides and peptidomimetics: an update.

Org Biomol Chem. 2015 Dec 8;

Authors: De Leon Rodriguez LM, Kaur H, Brimble MA

Abstract
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), an infection that has been declared a global public health emergency by the World Health Organization. Current anti-TB therapies are limited in their efficacy and have failed to prevent the spread of TB, due to the long term drug compliance required and the genesis of multidrug-resistant strains (MDR). The number of chemotherapeutic agents currently available to treat MDR is limited, therefore there is a great need for new anti-TB drugs. Anti-TB peptides and peptidomimetics have emerged as an important and growing class of chemotherapeutic agents. This mini-review provides an update on peptides that exhibit very potent anti-TB activity, and their chemical syntheses, which could potentially be included in the pipeline for new anti-TB drug development.

PMID: 26645944 [PubMed - as supplied by publisher]