Tedizolid (TR-701): a new oxazolidinone with enhanced potency.

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Tedizolid (TR-701): a new oxazolidinone with enhanced potency.

Expert Opin Investig Drugs. 2012 Apr;21(4):515-22

Authors: Kanafani ZA, Corey GR

INTRODUCTION: Tedizolid phosphate (TR-701) is a new oxazolidinone prodrug that is transformed in the serum into the active drug tedizolid (TR-700). Tedizolid acts by inhibiting protein synthesis and has broad activity against Gram-positive pathogens, including strains that are resistant to linezolid.
AREAS COVERED: This review summarizes the currently available data on this new antimicrobial agent. In vitro activity, pharmacokinetics/pharmacodynamics, clinical efficacy and safety are all addressed.
EXPERT OPINION: Tedizolid will provide a useful addition to the antimicrobial armamentarium, particularly in complicated skin and skin structure infections, due to its high oral bioavailability and once-daily dosing. The results of future studies will serve to better position tedizolid among the newly approved agents for infections caused by Gram-positive organisms.

PMID: 22324973 [PubMed - indexed for MEDLINE]