The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4

Chem Commun (Camb). 2021 May 11. doi: 10.1039/d1cc01838h. Online ahead of print.

ABSTRACT

pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.

PMID:33972964 | DOI:10.1039/d1cc01838h