The effect of pharmacy restriction of clindamycin on Clostridium difficile infection rates in an orthopedics ward.
Am J Infect Control. 2014 Jun;42(6):e71-3
Authors: Cruz-Rodríguez NC, Hernández-García R, Salinas-Caballero AG, Pérez-Rodríguez E, Garza-González E, Camacho-Ortiz A
A high consumption of clindamycin was noted in an orthopedics ward with high rates of Clostridium difficile infection (CDI). We restricted clindamycin for the entire ward. A reduction of 88% in CDI (1.07 to 0.12 × 1,000 patients-days, P = .056) and 84% for all-cause diarrhea (2.40 to 0.38 × 1,000 patients-days, P = .021) was achieved. Clindamycin was reduced 92.61% without an increase in other antibiotics. We identified high consumption of clindamycin as a risk factor for CDI.
PMID: 24837129 [PubMed - in process]