The effect of pharmacy restriction of clindamycin on Clostridium difficile infection rates in an orthopedics ward.

The effect of pharmacy restriction of clindamycin on Clostridium difficile infection rates in an orthopedics ward.

Am J Infect Control. 2014 Jun;42(6):e71-3

Authors: Cruz-Rodríguez NC, Hernández-García R, Salinas-Caballero AG, Pérez-Rodríguez E, Garza-González E, Camacho-Ortiz A

Abstract
A high consumption of clindamycin was noted in an orthopedics ward with high rates of Clostridium difficile infection (CDI). We restricted clindamycin for the entire ward. A reduction of 88% in CDI (1.07 to 0.12 × 1,000 patients-days, P = .056) and 84% for all-cause diarrhea (2.40 to 0.38 × 1,000 patients-days, P = .021) was achieved. Clindamycin was reduced 92.61% without an increase in other antibiotics. We identified high consumption of clindamycin as a risk factor for CDI.

PMID: 24837129 [PubMed - in process]