The effects of Japan’s National Action Plan on Antimicrobial Resistance on antimicrobial use.

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The effects of Japan's National Action Plan on Antimicrobial Resistance on antimicrobial use.

Int J Infect Dis. 2020 Nov 20;:

Authors: Kusama Y, Tsuzuki S, Muraki Y, Koizumi R, Ishikane M, Ohmagari N

Abstract
We sought to estimate the effects of Japan's National Action Plan on Antimicrobial Resistance 2016-2020 (NAP) on antimicrobial use (AMU). We calculated monthly AMU from January 2013 to December 2019 using sales data, then created time-series charts of AMU for the total antimicrobials and target drug categories shown in NAP (oral cephalosporins, oral fluoroquinolones, oral macrolides, and parenteral antimicrobials). Twelve-month predictions were generated to evaluate AMU in 2020. The publication of the NAP was associated with an AMU reduction in total antimicrobials, cephalosporins, fluoroquinolones, and macrolides. Parenteral AMU showed an upward trend, although it was not significantly associated with the intervention effect. We predicted AMU reductions of 15.0% for total antimicrobials, 26.3% for cephalosporins, 23.5% for fluoroquinolones, and 24.6% for macrolides in 2020 relative to 2013. However, there was a predicted increase of 17.4% for parenteral AMU. While Japan's NAP has contributed to the reduction of the national AMU over the past 5 years, sustained action is still needed to further improve antimicrobial stewardship and promote AMR countermeasures.

PMID: 33227519 [PubMed - as supplied by publisher]