The in vitro activity of tedizolid compared to linezolid and five other antimicrobial agents against 332 anaerobic isolates including Bacteroides fragilis group spp., Prevotella, Porphyromonas and Veillonella spp.

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The in vitro activity of tedizolid compared to linezolid and five other antimicrobial agents against 332 anaerobic isolates including Bacteroides fragilis group spp., Prevotella, Porphyromonas and Veillonella spp.

Antimicrob Agents Chemother. 2020 Jul 06;:

Authors: Goldstein EJC, Merriam CV, Citron DM

Abstract
Tedizolid's anaerobic activity is unappreciated; it was active against all 332 anaerobic isolates at ≤2 μg/ml except Bilophila wadsworthia, and was more active than linezolid against B. fragilis group sp. (MIC90 1 μg/ml vs 2-4 μg/ml). Tedizolid was active against Gram-positive anaerobes (MIC90: clostridia 0.25-1 μg/ml; anaerobic cocci ≤0.06 - 0.25 μg/ml). Coupled with clinical reports, clinicians should consider its use in mixed infections where S. aureus and anaerobes are involved.

PMID: 32631819 [PubMed - as supplied by publisher]