The interaction of echinocandin caspofungin with amphotericin B or voriconazole against the Aspergillus biofilms in vitro.
Liu W, Li L, Sun Y, Chen W, Wan Z, Li R, Liu W.
Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, Beijing, P. R. China.
Aspergillus biofilms were prepared in 22 strains of Aspergillus spp. via a 96-well plate-based method. Using a broth microdilution checkerboard technique with XTT colorimetric assaying, we demonstrated a synergistic antifungal activity with a combination of caspofungin and amphotericin B or voriconazole against 18 of 22 strains of Aspergillus biofilms, or 13 of 22 strains of Aspergillus biofilms. We did not observe antagonism.
- [PubMed – as supplied by publisher]