The Investigational Agent E1210 is Effective in the Treatment of Experimental Invasive Candidiasis Caused by Resistant Candida albicans.

The Investigational Agent E1210 is Effective in the Treatment of Experimental Invasive Candidiasis Caused by Resistant Candida albicans.

Antimicrob Agents Chemother. 2014 Oct 20;

Authors: Wiederhold NP, Najvar LK, Fothergill AW, McCarthy DI, Bocanegra R, Olivo M, Kirkpatrick WR, Everson MP, Duncanson FP, Patterson TF

Abstract
The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant C. albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandin resistant C. albicans, oral doses of E1210 10 and 40 mg/kg twice daily significantly improved survival and reduced fungal burden compared to controls and caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistant C. albicans infections.

PMID: 25331706 [PubMed - as supplied by publisher]