Therapeutic effects of three trichothecenes in the silkworm infection assay with Candida albicans.

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Therapeutic effects of three trichothecenes in the silkworm infection assay with Candida albicans.

Drug Discov Ther. 2016 Feb;10(1):44-8

Authors: Uchida R, Namiguchi S, Ishijima H, Tomoda H

Abstract
The silkworm infection assay is a useful method for directly evaluating the in vivo therapeutic effects of drug candidates. In the present study, 3 known trichothecenes, trichodermin, epiisororidin E, and verrucarin A, were evaluated as antifungal agents in the silkworm-Candida albicans assay. Trichodermin and epiisororidin E yielded effective therapeutic effects, while verrucarin A exhibited no efficacy in this assay system. These results strongly suggest that trichodermin and epiisororidin E are the lead compounds for developing a new antifungal agent.

PMID: 26971555 [PubMed - indexed for MEDLINE]