Time to sputum culture conversion and its associated factors among multidrug-resistant tuberculosis patients in Eastern Africa: A systematic review and meta-analysis.

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Time to sputum culture conversion and its associated factors among multidrug-resistant tuberculosis patients in Eastern Africa: A systematic review and meta-analysis.

Int J Infect Dis. 2020 Jun 11;:

Authors: Assemie MA, Alene M, Petrucka P, Leshargie CT, Ketema DB

Abstract
OBJECTIVE: The aim of this study was to consider the estimated time to multi-resistant tuberculosis culture conversion and its associated factors to enhance evidence utilization in eastern Africa.
METHODS: We systematically identified available articles on multidrug-resistant tuberculosis culture conversion using PubMed, Scopus, Cochrane Library, Web of Science core collection, and Science Direct databases. A random-effects model was undertaken using R 3.6.1 version and Stata/se 14 software.
RESULTS: Nine articles with a sample size of 2,458 multi-drug resistant tuberculosis patients were included. The two-month culture conversion rate was found to be 75.4% with median time 61.2 days (interquartile range: 48.6-73.8). Favorable treatment outcomes of MDR-TB patients in the included studies were seen in 75% of the cases while unfavorable treatment outcomes were seen in 18% (10% deaths, 7% defaulter, and 1% treatment failure) of the cases. The independent factor for delayed sputum culture conversion was body mass index below 18.5kg/m2 (HR=3.1, 95% CI: 2.0, 6.7).
CONCLUSION: The median time to sputum culture conversion was found to be 61.2 days which is a reasonably short time. Body mass index was the identified associated factor leading to delayed culture conversion. Therefore, there is a need for awareness creation on how to improve the nutrition status of multidrug-resistant tuberculosis patients through appropriate nutritional supports.

PMID: 32535296 [PubMed - as supplied by publisher]