TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model.

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TLR2 modulates gut colonization and dissemination of Candida albicans in a murine model.

Microbes Infect. 2016 May 30;

Authors: Prieto D, Carpena N, Maneu V, Gil ML, Pla J, Gozalbo D

Abstract
Invasive candidiasis often arises from translocation of endogenous yeasts from the gastrointestinal tract to the bloodstream. Here we describe that both wild type and TLR2-/- mice strains, orally administered with Candida albicans yeasts, display similar sustained high level of gut colonization when oral antibacterial treatment is present, while removal of antibiotic treatment causes a progressive clearance of yeasts in control but not in TLR2-/- mice. Fungal invasion of internal organs, following immunosuppression of colonized mice, was increased in TLR2-/- mice. These results point out to a role of TLR2 in gut protection against colonization and endogenous invasion by C. albicans.

PMID: 27256463 [PubMed - as supplied by publisher]