Trailing or Paradoxical Growth of Aspergillus flavus upon exposure to caspofungin is independent from genotypes.
J Med Microbiol. 2014 Sep 10;
Authors: Hadrich I, Neji S, Makni F, Ayadi A, Elloumi M, Ranque S
Data on in vitro susceptibility testing of echinocandins against Aspergillus species are sparse. The objective of this study was to describe the phenotypes of A. flavus when exposed in vitro to caspofungin and to test whether they were associated to genotype. The caspofungin MICs of 37 A. flavus clinical isolates collected from13 patients with invasive aspergillosis where determined using the Etest assay. The caspofungin MICs ranged from 0.012 to 0.064 mg/L; modal MIC was 0.023 mg/L; the MIC50 and MIC90 where 0.032 and 0.064 mg/L, respectively. A clear end point was noted in 24 (65%) isolates, whereas 7 (19%) displayed a trailing effect and 6 (16%) a paradoxical growth when exposed to caspofungin. In these A. flavus isolates, the absence of significant population structure or genetic differentiation indicated that trailing or paradoxical growth phenotypes were independent from microsatellite genotype.
PMID: 25210202 [PubMed - as supplied by publisher]