Updates in the Management of Cephalosporin-Resistant Gram-Negative Bacteria.

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Updates in the Management of Cephalosporin-Resistant Gram-Negative Bacteria.

Curr Infect Dis Rep. 2016 Dec;18(12):39

Authors: Arizpe A, Reveles KR, Patel SD, Aitken SL

Abstract
Resistance to cephalosporins is now common among Gram-negative bacterial infections, including those caused by the Enterobacteriaceae and Pseudomonas aeruginosa, posing a major threat to public health. As resistance to the traditional drugs of choice for these infections, carbapenems, has also become increasingly common, interest in cefepime and piperacillin-tazobactam as carbapenem-sparing alternatives has increased. Additionally, the availability of the novel β-lactam-β-lactamase inhibitor combinations ceftolozane-tazobactam and ceftazidime-avibactam has added to the antimicrobial armamentarium available to treat these multidrug-resistant infections. Here, we review the recent literature on the use of carbapenem-sparing alternatives and highlight the potential utility of novel antimicrobials.

PMID: 27743202 [PubMed - in process]