[Use of molecular typing tools for the study of hospital outbreaks of candidemia.]
Rev Iberoam Micol. 2013 Jun 19;
Authors: Marcos-Zambrano LJ, Escribano P, Bouza E, Guinea J
Candidemia is an infectious complication mainly affecting hospital patients, particularly those admitted to intensive care units. Patient mortality can reach up to 40%. Candidemia is typically nosocomially-acquired, and horizontal transmission of Candida spp. can lead to the presence of outbreaks of candidemia. Genotyping of isolates of Candida spp. causing candidemia can help us understand the source of the infection, detect the hospital wards with active Candida spp. transmission, and consequently, improve the prevention of the infection. Several genotyping tools have been use for the molecular characterization of Candida spp. isolates involved in outbreaks of candidemia. Genotyping procedures based on microsatellites are reproducible and show a high discriminatory power. Microsatellites are recommended for the study of outbreaks of candidemia. Most hospital outbreaks of candidemia have involved patients admitted to intensive care units, mostly neonatal. The role of genotyping of Candida spp. isolates causing candidemia for the study of nosocomial outbreaks of candidemia is reviewed, as well as the patients more commonly affected by epidemic strains.
PMID: 23792122 [PubMed - as supplied by publisher]