Use of vaccines as a key antimicrobial stewardship strategy.
S Afr Med J. 2015 May;105(5):7409
Authors: Brink AJ, Richards GA
Vaccination may prevent bacterial infections and decrease the potential for transmission. Some effective vaccines may reduce bacterialcolonisation and exposure to antimicrobials by minimising the spread of resistant strains; in this regard, a substantial indirect immunity hasbeen demonstrated that protects unvaccinated members of society. One of the best documented examples of the crucial role of vaccinationhas been an adjunct to an antimicrobial stewardship programme. Pneumococcal conjugate vaccines (PCVs), for example, target the mostvirulent pneumococcal serotypes, which are linked to invasive disease and associated with antibiotic resistance. In this regard, recent localdata highlight the remarkable impact of the sequential introduction of 7- and 13-valent PCV (PCV7/PCV13) on the incidence of penicillin-,ceftriaxone- and multidrug-resistant pneumococcal infections in South Africa in only 4 years. Equally impressive have been vaccinesdirected towards viruses such as influenza, which also have direct and indirect effects on antibiotic consumption.
PMID: 26242678 [PubMed - in process]