What is behind phylogenetic analysis of hospital, community and livestock associated methicillin-resistant Staphylococcus aureus?

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What is behind phylogenetic analysis of hospital, community and livestock associated methicillin-resistant Staphylococcus aureus?

Transbound Emerg Dis. 2019 Mar 20;:

Authors: Abd El-Hamid MI, Bendary MM, Merwad AMA, Ghaith DM, Alshareef WA

Abstract
Methicillin resistant Staphylococcus aureus (MRSA) has been shown to be the predominant life-threatening pathogen in Egypt. MRSA is a major cause of severe healthcare-associated (HA) infections. During the last decades, the incidence of community-associated (CA) MRSA infections has a complex epidemiology arising from the circulation of different strains in the general population. Moreover, livestock-associated (LA) MRSA emerged recently becomes an emerging threat to public health. Therefore, it's important to illuminate the differences between CA-, HA and LA-MRSA to shed light on their genetic diversity and evolution.This study presents the first data on analyzing the correlation between CA-, LA- and HA-MRSA using antibiogram typing, molecular characteristics and antimicrobial resistance and virulence genes' profiles. Overall, HA-MRSA strains tended to be multidrug resistant and less virulent than both LA-and CA- MRSA strains. Importantly, CA-MRSA strains had a high homology with each of HA-and LA-MRSA. However, no similarity was observed between HA- and LA-MRSA. Our findings suggest that the epidemiological changes in genetic behaviour between HA- and LA-MRSA are due to the presence of CA-MRSA confirming that CA-MRSA has created a public health crisis worldwide. This article is protected by copyright. All rights reserved.

PMID: 30892827 [PubMed - as supplied by publisher]